ILEI is an important intermediate participating in the formation of TGF ‐β1–induced renal tubular EMT

In conclusion, ILEI appears to play a crucial role in mediating TGF‐β1–induced EMT through the Akt and ERK pathways, which may provide a therapeutic target for the treatment of fibrotic kidney diseases. Significance of the studyThere is no study reporting the effect of ILEI in renal EMTs. In this research, we examined the role and mechanism of ILEI in EMT using tubular epithelial cell; we found that ILEI participated in renal tubular EMT, and overexpression of ILEI can not only induce EMT of HK‐2 cells independently but also enhance EMT in response to TGF‐β1. Meanwhile, we found ILEI small interfering RNA blocked the EMT induced by TGF‐β1, and ILEI participates in the EMT caused by TGF‐β1 via ERK and Akt signalling pathways. We hoped to provide new ideas in further study on the prevention and treatment of fibrotic kidney diseases.
Source: Cell Biochemistry and Function - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research