Gray and white matter changes and their relation to illness trajectory in first episode psychosis

Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non-schizophrenia).

Source: European Neuropsychopharmacology - January 12, 2018 Category: Psychiatry & Psychology Authors: Alejandro Keymer-Gausset, Anna Alonso-Sol ís, Iluminada Corripio, Rosa B. Sauras-Quetcuti, Edith Pomarol-Clotet, Erick J. Canales-Rodriguez, Eva Grasa-Bello, Enric Álvarez, Maria J. Portella Source Type: research