Acute and Chronic Increases of Circulating FSTL1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure [Original Articles]

Conclusions
These findings support a novel function for FSTL1 and provide the first direct evidence that a circulating cardiokine/myokine can alter myocardial and systemic energy substrate metabolism, in vivo.

Source: Circulation: Heart Failure - January 9, 2018 Category: Cardiology Authors: Seki, M., Powers, J. C., Maruyama, S., Zuriaga, M. A., Wu, C.-L., Kurishima, C., Kim, L., Johnson, J., Poidomani, A., Wang, T., Munoz, E., Rajan, S., Park, J. Y., Walsh, K., Recchia, F. A. Tags: Animal Models of Human Disease, Growth Factors/Cytokines, Metabolism, Heart Failure Original Articles Source Type: research