Performance of the BioPlex 2200 HIV Ag-Ab assay for identifying acute HIV infection

Screening for HIV infection can be performed with assays that detect HIV antibody (Ab) only (3rd generation assays) or with combination assays that detect HIV antigen (Ag) and Ab [1,2]. The ability to detect HIV Ag in addition to Ab can shorten the window period for detection of HIV infection [3,4]. Assays that provide one test result for Ag and/or Ab are often referred to as 4th generation assays. These assays can detect acute (Ag-positive/Ab-negative) HIV infections [5]. Some Ag/Ab assays provide separate test results for HIV Ag and Ab [3]; these assays have the potential to identify acute infections.

Source: Journal of Clinical Virology - January 11, 2018 Category: Virology Authors: Susan H. Eshleman, Estelle Piwowar-Manning, Mariya V. Sivay, Barbara Debevec, Stephanie Veater, Laura McKinstry, Linda-Gail Bekker, Sharon Mannheimer, Robert M. Grant, Margaret A. Chesney, Thomas J. Coates, Beryl A. Koblin, Jessica M. Fogel Tags: Short communication Source Type: research