Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy

Human enterovirus D68 (EV-D68) was originally isolated in 1962, and for many years it was considered a rare cause of respiratory disease because it was identified in isolated cases and in small outbreaks [1]. Although outbreaks of EV-D68 infection occurred in the Philippines [2], Italy [3,4], the Netherlands [5] and Japan [6] between 2005 and 2012, it was only in 2014 that the virus gained epidemiological and clinical relevance. In that year, a large-scale outbreak of severe respiratory infections due to this agent, in some cases associated with central nervous system diseases, occurred in the USA and Canada [7], with subsequent cases in other countries [8 –16].

Source: Journal of Clinical Virology - January 11, 2018 Category: Virology Authors: Antonio Piralla, Nicola Principi, Luca Ruggiero, Alessia Girello, Federica Giardina, Elisabetta De Sando, Silvia Caimmi, Sonia Bianchini, Gian Luigi Marseglia, Giovanna Lunghi, Fausto Baldanti, Susanna Esposito Source Type: research