An endochondral ossification approach to early ‐stage bone repair: Use of tissue‐engineered hypertrophic cartilage constructs as primordial templates for weight‐bearing bone repair

In this study, we demonstrate that tissue‐engineered hypertrophically‐primed cartilage constructs can be developed from collagen‐based scaffolds cultured with mesenchymal stem cells. These constructs were subsequently implanted into femoral defects in rats. It was evident that the constructs could support enhanced early‐stage healing at 4 weeks of these weight‐bearing femoral bone defects compared to untreated defects.

Source: Journal of Tissue Engineering and Regenerative Medicine - January 11, 2018 Category: Biotechnology Authors: Amos Matsiko, Emmet M. Thompson, Cai Lloyd ‐Griffith, Gráinne M. Cunniffe, Tatiana Vinardell, John P. Gleeson, Daniel J. Kelly, Fergal J. O'Brien Tags: SHORT COMMUNICATION Source Type: research