Long term (4 years) improved insulin sensitivity following islet cell transplant in type 1 diabetes

ConclusionsInsulin sensitivity measured by SIis was improved several years following transplant, while IS measured by HOMA‐IR did not worsen. Higher exenatide dose, more islets transplanted, and diet and exercise (lowering leptin and receptor activator of nuclear factor kappa‐B ligand) may improve IS, which may enhance glycaemic control and lower metabolic demand on transplanted islets. Long‐term clamp studies are needed to confirm these results.

Source: Diabetes/Metabolism Research and Reviews - January 11, 2018 Category: Endocrinology Authors: Brett Rydzon, Rebecca S. Monson, Jose Oberholzer, Krista A. Varady, Melena D. Bellin, Kirstie K. Danielson Tags: RESEARCH ARTICLE Source Type: research