Contractile effect of rifaximin on bovine uterus in the presence of steroid hormone antagonists

This in vitro study investigated the modulatory effect of rifaximin on bovine uterus contractility, in both phases of the oestrous cycle, with and without the steroid hormones that are predominant in the respective phases: oestrogen in the follicular phase and progesterone in the luteal phase. The procedures were conducted in an isolated organ bath by using rifaximin alone (10 −4 M) and in association with the steroid hormone antagonists (10−5 M) tamoxifen (oestrogen antagonist) in the follicular phase and mifepristone (progesterone antagonist) in the luteal phase.
Source: Theriogenology - Category: Genetics & Stem Cells Authors: Source Type: research