Two Pools of Epoxyeicosatrienoic Acids in HumansNovelty and Significance [Epoxyeicosatrienoic Acid and Salt Sensitivity]

We report ultra-performance liquid chromatography/tandem mass spectrometry plasma EETs, DHETs, and their sum (plasma total pool) for the 3 regioisomers (8,9-, 11,12-, 14,15-) and their sum (08,15-). In salt-resistant subjects, urine total pool was unchanged by HiNa, decreased by LoNa, and correlated with urine sodium excretion, fractional excretion of Na+, and Na+/K+ ratio for the 3 days of the experiment combined (P

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Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Fernando Elijovich, Ginger L. Milne, Nancy J. Brown, Michal Laniado-Schwartzman, Cheryl L. Laffer Tags: Clinical Studies, Mechanisms, Pathophysiology, High Blood Pressure Original Articles Source Type: research