Podocytes are new cellular targets of haemoglobin ‐mediated renal damage

In conclusion, podocytes take up Hb both in vitro and during intravascular haemolysis, promoting oxidative stress, podocyte dysfunction, and apoptosis. Nrf2 may be a potential therapeutic target to prevent loss of renal function in patients with intravascular haemolysis. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Source: The Journal of Pathology - January 10, 2018 Category: Pathology Authors: Alfonso Rubio ‐Navarro, Maria Dolores Sanchez‐Niño, Melania Guerrero‐Hue, Cristina García‐Caballero, Eduardo Gutiérrez, Claudia Yuste, Ángel Sevillano, Manuel Praga, Javier Egea, Elena Román, Pablo Cannata, Rosa Ortega, Isabel Cortegano, Bel� Tags: Original Paper Source Type: research