miRNA-185 regulates the VEGFA signaling pathway in dairy cows with retained fetal membranes

Retention of fetal membranes (RFM) of cows is an important reproductive disturbance, and is related to miRNAs. Vascular endothelial growth factor (VEGF)A, regulated by miRNA-185, can activate arachidonic acid (ARA) release via the VEGFA signaling pathway, which influences RFM. The aim of this study was to explore the pathogenic mechanism of RFM by investigating the regulatory relationship between miRNA-185 and the VEGFA signaling pathway. Serum samples of healthy Holstein dairy cows (n  = 20) and RFM cows (n = 12), with a similar age, parity, weight, and milk yield, were collected to detect VEGFA and ARA concentrations at 6, 12, and 24 h after calving.

Source: Theriogenology - January 9, 2018 Category: Genetics & Stem Cells Authors: C.Y. Zheng, X. Zou, H.J. Lin, B.C. Zhao, M.L. Zhang, C.H. Luo, S.X. Fu Source Type: research