Antimicrobial Emulsifier –Glycerol Monolaurate Induces Metabolic Syndrome, Gut Microbiota Dysbiosis, and Systemic Low‐Grade Inflammation in Low‐Fat Diet Fed Mice

ConclusionOur results indicate that relatively low‐dose GML consumption promotes metabolic syndrome, gut microbiota dysbiosis, and systemic low‐grade inflammation, thereby calling for a reassessment of GML usage. Glycerol monolaurate (GML) induced metabolic syndrome, gut microbiota dysbiosis, and circulating low‐grade inflammation by significantly increasing the body fat percentage and epididymal fat; exacerbating serum lipid profiles disorder and histopathologic abnormality of epididymal adipose tissue; changing the composition and metabolic function of gut microbiota; and upregulating the production of the serum lipopolysaccharides (LPS) concentration and circulating inflammatory cytokines mainly involved in IL‐1β, IL‐6, and TNF‐α. The dotted arrows represent a mechanism that requires further proof.
Source: Nahrung / Food - Category: Nutrition Authors: Tags: RESEARCH ARTICLE Source Type: research