Compatibility of common IV drugs with 6% hydroxyethyl starch 130/0.42 and 4% gelatin

ConclusionMost of the tested drugs did not show observable incompatibility reactions. However, some common drugs are highly incompatible with colloid infusion solutions: gelatin (cefazolin, diazepam, midazolam, phenytoin, vancomycin), hydroxyethyl starch (diazepam, midazolam, phenytoin, thiopental), and NaCl 0.9% (diazepam, ketamine (S), phenytoin, thiopental). These combinations should be avoided in clinical practice in case there are fewer intravenous lines available than needed.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fpan.13309

Source: Pediatric Anesthesia - January 1, 2018 Category: Anesthesiology Authors: Sebastian Heiderich, Anna Springe, Jonas J ürgens, Wolfgang Koppert, Andreas Leffler, Robert Sümpelmann, Nils Dennhardt Tags: RESEARCH REPORT Source Type: research