Performance of genotypic algorithms for predicting tropism for HIV-1 CRF01_AE recombinant

The chemokine receptors CCR5 and CXCR4 are the principal co-receptors for entry of HIV-1 into target cells [1,2]. Co-receptor selectivity is determined by genetic sequences within HIV glycoprotein 120 (gp120), particularly in a highly variable and structurally flexible region termed ‘V3′ which is involved in co-receptor binding [3–5]. The CCR5 antagonists, which inhibit HIV-1 binding on the CCR5-coreceptor, are only active on R5-tropic viruses which implies a tropism determination before their prescription.

Source: Journal of Clinical Virology - January 8, 2018 Category: Virology Authors: C. Soulie, L. Morand-Joubert, J. Cottalorda, C. Charpentier, P. Bellecave, L. Le Guen, S. Yerly, B. Montes, S. Fafi-Kremer, J. Dina, V. Avettand-Fenoel, C. Amiel, C. Roussel, C. Pallier, K. Zafilaza, S. Sayon, A. Signori-Schmuck, A. Mirand, M.A. Trabaud, Tags: Short communication Source Type: research