BRCA1 mutation spectrum, functions and therapeutic strategies: The story so far

Breast Cancer is not only one of the most commonly diagnosed cancer (23%) but also a leading cause of cancer-related deaths (14%) among women world over.1 In 2015, WHO estimated 231,840 new cases of invasive breast cancer and 60,290 additional in situ cases. The incidence rate varies drastically across the world, ranging from 92 per 100,000 in North America to 27 per 100,000 in Middle Africa and Eastern Asia.1 The Ashkenazi population represents the Jews having ancestors from Eastern and Central Europe, such as Germany, Poland, Lithuania, Ukraine, and Russia.

Source: Current Problems in Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Babita Sharma, Raman Preet Kaur, Sonali Raut, Anjana Munshi Source Type: research