Receiver operating characteristic curve analysis of four Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis

Measurement of Aspergillus-specific IgG is central to the diagnosis of chronic pulmonary aspergillosis (CPA), but manufacturers ’ guidance on test interpretation is based on unpublished data. We performed the first receiver operating characteristic (ROC) area under the curve (AUC) analysis to identify optimal cut-offs for this test in relation to European controls. Aspergillus-specific IgG levels were measured in sera from British adults with CPA and European healthy controls by ImmunoCAP, Immulite, Serion and Bio-Rad assays.

Source: Diagnostic Microbiology and Infectious Disease - January 5, 2018 Category: Microbiology Authors: Iain D Page, Caroline Baxter, Christophe Hennequin, Malcolm D Richardson, Erna van Hoeyveld, Albert W van Toorenenbergen, David W Denning Source Type: research