Liaison between Heme Metabolism and Bioenergetics Pathways-A Multimodal Elucidation for Early Diagnosis of Oral Cancer

Proposed role of cigarette smoking on cellular metabolic pathways. The schematic diagram shows heme metabolism that takes place in mitochondria and cytoplasm, and how the pathway is impaired under long exposure to smoking. NADH and FAD from TCA and other path ways in mitochondria are affected and the redox is imbalanced. Expression of ALAS1 gene in mitochondria is increased after cigarette smoking leading to over synthesis of PpIX. Excess PpIX is toxic for cells and is excreted out form the cells through ABCG2 channel.

Source: Photodiagnosis and Photodynamic Therapy - January 4, 2018 Category: Laser Surgery Authors: Ripon Sarkar, Kabita Chaterjee, Durbadal Ojha, Bijurica Chakraborty, Sanghamitra Sengupta, Debprasad Chattopadhyay, Chirasree RoyChaudhuri, Ananya Barui Source Type: research