In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid ‐β Kinetics and Neuroprotection

ConclusionMelatonin and other related indolic compounds, mainly serotonin, show an inhibitory and destabilizing effect on amyloid‐β peptide fibril formation and they possess neuroprotective properties related to the vitagenes system. Melatonin is a neurohormone derived from tryptophan in a multistep process involving serotonin and other intermediates which are present in food. In this work, the protective effects against amyloid‐β aggregation and cytotoxicity of eight indolic compounds are evaluated. The present study shows that serotonin is the most effective compound to inhibit amyloid‐β peptide aggregation. Almost all the indolic compounds tested prevent amyloid‐β peptide‐induced toxicity. These results support that indole‐derived compounds can be considered promising bioactives against the neuropathological features of Alzheimer's disease.
Source: Nahrung / Food - Category: Nutrition Authors: Tags: RESEARCH ARTICLE Source Type: research