Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes

Advanced glycation endproducts (AGEs) and altered extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) are associated with vascular complications in type 1 diabetes. Experimental studies have shown that AGEs regulate the production of MMPs and/or TIMP-1. Therefore, we investigated associations between specific AGEs and MMP-1, -2, -3, -9, and -10, and TIMP-1 in individuals with type 1 diabetes.

Source: Journal of Diabetes and Its Complications - January 3, 2018 Category: Endocrinology Authors: S.A. Peeters, L. Engelen, J. Buijs, S. Theilade, P. Rossing, C.G. Schalkwijk, C.D.A. Stehouwer Tags: Original article Source Type: research