Heterogeneity in effects of genetically determined adiposity on insulin resistance and type 2 diabetes: The atherosclerosis risk in communities study

A recent genome-wide association study has identified 12 genetic variants robustly associated with body fat percentage (BF%) with diverse cardiometabolic consequences. We developed three genetic risk scores (GRSs) according to the associations of the 12 individual variants with type 2 diabetes (T2D) and test the GRSs' associations with insulin resistance and T2D in the Atherosclerosis Risk in Communities Study.

Source: Journal of Diabetes and Its Complications - January 3, 2018 Category: Endocrinology Authors: Tingting Liu, Changwei Li, Luqi Shen, Ye Shen, Weibo Mao, Shengxu Li Tags: Original article Source Type: research