Evaluation of 4 Molecular Assays as Part of a 2-Step Algorithm for the Detection of Clostridium difficile in Stool Specimens

This study evaluated the performance of 4 nucleic acid amplification test (NAAT) assays as part of a 2-step algorithm that involves reflexive NAAT following enzyme immunoassay (EIA) testing that is indeterminate for glutamate dehydrogenase (GDH) antigen and toxin A/B (GDH+/toxin − or GDH−/toxin+). A total of 500 stool specimens from consecutive patients were tested by each of the 5 methods and also evaluated as part of a 2-step algorithm.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research