Antimicrobial Activity of Ceftobiprole and Comparator Agents When Tested against Contemporary Gram-Positive and -Negative Organisms Collected from Europe (2015)

Susceptibility testing of ceftobiprole and comparators against 12,240 isolates was performed following CLSI/EUCAST guidelines. The percentage of susceptible MRSA isolates was higher for ceftobiprole (96.5% susceptible) than for ceftaroline (86.2% susceptible). Both ceftobiprole (MIC50/90, 0.5/2 mg/L) and ceftaroline (MIC50/90, 0.25/1 mg/L) demonstrated potent activity against coagulase-negative staphylococci. Ceftobiprole demonstrated good potency against Enterococcus faecalis (MIC50/90 values of 0.5/2 mg/L); ceftaroline (MIC50/90, 2/8 mg/L) was 4-fold less active against these strains.

Source: Diagnostic Microbiology and Infectious Disease - January 3, 2018 Category: Microbiology Authors: MA Pfaller, RK Flamm, LR Duncan, JM Streit, M Castanheira, HS Sader Source Type: research