Effect of 17 ‐allylamino‐17‐demethoxygeldanamycin (17‐AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expression

ConclusionThese data allow us to speculate on the particular utility of 17‐AAG for HNSCC treatment through the inhibition of Akt protein expression, especially in the cases that retain the expression of PTEN protein.This article is protected by copyright. All rights reserved.

Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Fl ávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Adriana Souza de Jesus, Andrea Maia Correa Joaquim, Ligia Akiko Ninokata Miyahara, Felipe Paiva Fonseca, Décio dos Santos Pinto Júnior Tags: Original Article Source Type: research