GABA and Glutamate in Children with Tourette syndrome: A 1H MR Spectroscopy Study at 7 T

Tourette syndrome (TS) is characterized by presence of chronic, fluctuating motor and phonic tics. The underlying neurobiological basis for these movements is hypothesized to involve cortical-striatal-thalamo-cortical (CSTC) pathways. Two major neurotransmitters within these circuits are γ-aminobutyric acid (GABA) and glutamate. Seventy-five participants (32 with TS, 43 controls) ages 5–12 years completed 1H MRS at 7T. GABA and glutamate were measured in dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex (VMPFC), premotor cortex (PMC), and striatum, and metabo lites quantified using LCModel.

Source: Psychiatry Research: Neuroimaging - January 2, 2018 Category: Psychiatry Authors: E. Mark Mahone, Nicolaas A. Puts, Richard A.E. Edden, Matthew Ryan, Harvey S. Singer Source Type: research