Cortical folding abnormalities in patients with schizophrenia who have persistent auditory verbal hallucinations

In schizophrenia temporal cortical volume loss differs between patients presenting with persistent auditory verbal hallucinations (pAVH) in contrast to those without hallucinatory symptoms (nAVH). However, it is unknown whether this deficit reflects a neural signature of neurodevelopmental origin or if abnormal temporal cortical volume is reflective of factors which may be relevant at later stages of the disorder. Here, we tested the hypothesis that local gyrification index (LGI) in regions of the temporal cortex differs between patients with pAVH (n=10) and healthy controls (n=14), and that abnormal temporal LGI discriminates between pAVH and nAVH (n=10).

Source: European Neuropsychopharmacology - January 2, 2018 Category: Psychiatry & Psychology Authors: Katharina M. Kubera, Philipp A. Thomann, Dusan Hirjak, Anja Barth, Fabio Sambataro, Nenad Vasic, Nadine D. Wolf, Karel Frasch, R. Christian Wolf Source Type: research