Kefir Peptides Prevent Hyperlipidemia and Obesity in High ‐Fat‐Diet‐Induced Obese Rats via Lipid Metabolism Modulation

ConclusionThese results demonstrate that kefir peptides treatment improves obesity via inhibition of lipogenesis, modulation of oxidative damage, and stimulation of lipid oxidation. Therefore, kefir peptides may act as an anti‐obesity agent to prevent body fat accumulation and obesity‐related metabolic diseases. The effects of kefir peptides on obese rats may occur through the inhibition of lipogenesis pathway by reduced the FAS enzyme and increased the p‐ACC protein and stimulation of the lipid oxidation pathway via increased expression of p‐AMPK, PPAR‐α, and CPT1. Administration of kefir peptides also significantly decreased the inflammatory response (TNF‐α, IL‐1β, and TGF‐β) to modulate oxidative damage.
Source: Nahrung / Food - Category: Nutrition Authors: Tags: FOOD & FUNCTION Source Type: research