Increased Levels of 27 ‐Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats

ConclusionsThis study indicates that the mechanisms of dietary cholesterol on learning and memory impairment may be involved in cholesterol metabolism and lysosome function with the increase of plasma 27‐OHC, thus resulting in Aβ formation and accumulation. Increased levels of 27‐hydroxycholesterol induced by dietary cholesterol in brain impairs the learning and memory of rats via disrupting cholesterol metabolism and lysosome dysfunction, resulting in Aβ formation and accumulation.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fmnfr.201700531

Source: Nahrung / Food - January 2, 2018 Category: Nutrition Authors: Xiaona Zhang, Chenyan Lv, Yu An, Quanri Liu, Hongguo Rong, Lingwei Tao, Ying Wang, Yushan Wang, Rong Xiao Tags: RESEARCH ARTICLE Source Type: research