Bias from outcome misclassification in immunization schedule safety research

ConclusionsIn immunization schedule studies, outcome misclassification may be non‐differential or differential to exposure. Overall outcome PPVs do not reflect the distribution of false positives by exposure and are poor indicators of bias in individual studies. Our results support QBA for immunization schedule safety research.

Source: Pharmacoepidemiology and Drug Safety - January 1, 2018 Category: Drugs & Pharmacology Authors: Sophia R. Newcomer, Martin Kulldorff, Stan Xu, Matthew F. Daley, Bruce Fireman, Edwin Lewis, Jason M. Glanz Tags: ORIGINAL REPORT Source Type: research