Predictive factors of spontaneous CMV DNAemia clearance in kidney transplantation

Cytomegalovirus (CMV) is still associated with increased morbidity and mortality following transplantation despite effective antiviral treatments [1 –4]. CMV affects allograft survival through “direct effects” such as inflammation enhanced and sustained by the virus, and through “indirect effects” mediated by the immune system [5–9]. Improvements in diagnostic assays such as Polymerase Chain Reaction (PCR) increased sensitivity compa red to the pp65 antigenemia assay for detecting CMV in the blood [10].

Source: Journal of Clinical Virology - December 29, 2017 Category: Virology Authors: Johan Noble, Philippe Gatault, B énédicte Sautenet, Catherine Gaudy-Graffin, Agnes Beby-Defaux, Antoine Thierry, Marie Essig, Jean-Michel Halimi, Eliza Munteanu, Sophie Alain, Matthias Buchler Source Type: research