Loading ‐Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late‐Stage Osteoarthritis

ConclusionSince focal stress on the SBP underlying sites of cartilage damage increases during late stages of OA, these findings establish mechanical loading–induced attenuation of sclerostin expression and elevation of bone formation along the SBP surface as the major mechanisms characterizing subchondral bone phenotypes associated with severe late‐stage OA in mice.

Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Haoruo Jia, Xiaoyuan Ma, Yulong Wei, Wei Tong, Robert J. Tower, Abhishek Chandra, Luqiang Wang, Zeyang Sun, Zhaochun Yang, Farid Badar, Kairui Zhang, Wei ‐Ju Tseng, Ina Kramer, Michaela Kneissel, Yang Xia, X. Sherry Liu, James H. C. Wang, Lin Han, Motom Tags: Original Article Source Type: research