High levels of DEK autoantibodies in sera of polyarticular JIA patients and in early flare following cessation of anti ‐TNF therapy

ConclusionsDEK autoantibody levels are higher in patients with polyarticular, rather than oligoarticular, JIA and in patients who flare after cessation of anti‐TNF therapy. The C‐terminal 25 aa is the most immunogenic portion of DEK. These findings are of significance with respect to the nature of DEK autoantibodies and their contribution to the pathogenesis and management of JIA.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Nirit Mor ‐Vaknin, Miguel Rivas, Maureen Legendre, Smriti Mohan, Ye Yuanfan, Theresa Mau, Anne Johnson, Bin Huang, Lili Zhao, Yukiko Kimura, Steven J. Spalding, Paula W. Morris, Beth S. Gottlieb, Karen Onel, Judyann C. Olson, Barbara S. Edelheit, Michae Tags: Full Length Source Type: research