Effects of HLA ‐B27 on Gut Microbiota in Experimental Spondyloarthritis Implicate an Ecological Model of Dysbiosis

ConclusionEffects of HLA‐B27 on gut microbiota and dysbiosis in SpA are highly dependent on host genetic background and/or environment despite convergence of dysregulated immune pathways. These results indicate an ecological model of dysbiosis where the effects of multiple microbes contribute to the aberrant immune response, rather than a single or small number of microbes driving pathogenesis.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Full Length Source Type: research