MMP ‐3 (–1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)‐3 and correlate with severity of COPD: A study of MMP‐3, MMP‐7 and MMP‐12 in a Tunisian population
ConclusionsMMP‐3 (–1171) 5A/6A and Lys45Glu (A/G) polymorphisms were associated with the decline of lung function among COPD patients. These results could be linked to the upregulation of MMP‐3 in serum from COPD patients carrying the (–1171) 6A and 45 G homozygous genotypes.
Source: The Journal of Gene Medicine - Category: Genetics & Stem Cells Authors: Sarra Bchir, Hela Nasr, Abdelhamid Garrouch, Amel Anes, Ammar Abbassi, Zouhair Tabka, Karim Chahed Tags: RESEARCH ARTICLE Source Type: research