Oral cancer-derived exosomal NAP1 enhances cytotoxicity of natural killer cells via the IRF-3 pathway

Oral cancer (OC) is one of the most common cancers in the world, four-fifths of what occurred in developing countries [1,2]. The major treatments for OC are still primarily conventional therapies, i.e., surgery, radiotherapy and chemotherapy. Many patients with OC are diagnosed at locally advanced stages, and OC cases with distant metastasis or recurrence lack effective therapies. Immunotherapy has recently proved effective for several malignant tumor types, including OC. However, a systematic increase in median progression-free survival has not been observed [3,4].

Source: Oral Oncology - December 1, 2017 Category: Cancer & Oncology Authors: Yingnan Wang, Xing Qin, Xueqin Zhu, Wanjun Chen, Jianjun Zhang, Wantao Chen Source Type: research