Osseointegration and foreign body reaction: Titanium implants activate the immune system and suppress bone resorption during the first 4 weeks after implantation

ConclusionsThe presence of a titanium implant during bone healing activates the immune system and displays type 2 inflammation, which is likely to guide the host‐biomaterial relationship. At the same time, bone resorption is suppressed around titanium sites compared to sham sites after 4 weeks of implantation, suggesting a shift to a more pronounced bone forming environment. This suggests two important steps in osseointegration: identification of the titanium foreign body by the immune system and the development of a bone forming environment, that at tissue level translates into bone build‐up on the titanium surface and can be perceived as an attempt to isolate the foreign body from the bone marrow space.

Source: Clinical Implant Dentistry and Related Research - December 1, 2017 Category: Dentistry Authors: Ricardo Trindade, Tomas Albrektsson, Silvia Galli, Zdenka Prgomet, Pentti Tengvall, Ann Wennerberg Tags: ORIGINAL ARTICLE Source Type: research