Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders

ConclusionOur developed filtering and validation approaches will be useful to identify somatic mutations in the human brain. The vulnerability of neuron‐expressed genes to mutational events suggests their potential relevance to neuropsychiatric diseases.

Source: Psychiatry and Clinical Neurosciences - December 1, 2017 Category: Neuroscience Authors: Masaki Nishioka, Miki Bundo, Junko Ueda, Katsuoka Fumiki, Yukuto Sato, Yoko Kuroki, Takao Ishii, Wataru Ukai, Shigeo Murayama, Eri Hashimoto, Masao Nagasaki, Jun Yasuda, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamoto Tags: Regular Article Source Type: research