MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB –NFIB fusion gene

In conclusion, we demonstrate that MYBL1 rearrangements and MYB amplification probably constitute alternative genetic drivers of breast AdCCs, functioning through MYBL1 or MYB overexpression. These observations emphasize that breast AdCCs probably constitute a convergent phenotype, whereby activation of MYB and MYBL1 and their downstream targets can be driven by the MYB–NFIB fusion gene, MYBL1 rearrangements, MYB amplification, or other yet to be identified mechanisms. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Source: The Journal of Pathology - December 28, 2017 Category: Pathology Authors: Jisun Kim, Felipe C Geyer, Luciano G Martelotto, Charlotte KY Ng, Raymond S Lim, Pier Selenica, Anqi Li, Fresia Pareja, Nicola Fusco, Marcia Edelweiss, Rahul Kumar, Rodrigo Gularte ‐Merida, Andre N Forbes, Ekta Khurana, Odette Mariani, Sunil Badve, Anne Tags: Brief Definitive Report Source Type: research