Cancer: Inhibiting DNA damage signalling

Nature Reviews Drug Discovery 17, 18 (2018). doi:10.1038/nrd.2017.261 Author: Sarah Crunkhorn The DNA transposase, piggyBac transposable element-derived 5 (PGBD5), is expressed in the majority of childhood solid tumours, where it promotes site-specific genomic rearrangements. Henssen et al. hypothesized that PGBD5-expressing cells may depend on active DNA damage repair and signalling for survival. Indeed, cell lines
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research