Cancer: Inhibiting DNA damage signalling
Nature Reviews Drug Discovery 17, 18 (2018).
doi:10.1038/nrd.2017.261
Author: Sarah Crunkhorn
The DNA transposase, piggyBac transposable element-derived 5 (PGBD5), is expressed in the majority of childhood solid tumours, where it promotes site-specific genomic rearrangements. Henssen et al. hypothesized that PGBD5-expressing cells may depend on active DNA damage repair and signalling for survival. Indeed, cell lines
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Sarah Crunkhorn Tags: Research Highlight Source Type: research
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