Molecular imaging of platelet-derived growth factor receptor-alpha (PDGFR α) in papillary thyroid cancer using immuno-PET

Receptor tyrosine kinase (RTK) platelet-derived growth factor receptor-alpha (PDGFR α) was recently identified as a molecular switch for dedifferentiation in thyroid cancer that predicts resistance to therapy as well as recurrence of disease in papillary thyroid cancer. Here we describe the radiolabeling and functional characterization of an imaging probe based on a PDGFRα-specif ic monoclonal antibody (mAb) for immuno-PET imaging of PDGFRα in papillary thyroid cancer.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research