Safety evaluation of subchronic feeding of nisI transformed Lactobacillus plantarum in Sprague ‐Dawley rats

In this study, six groups of Sprague‐Dawley (three groups/sex) rats were orally administered with Lp, Lp590 or physiological saline for 90 days. Nutritional status and growth performance were evaluated followed by analysis of blood biochemistry, hematology and organ variables. Compared with control, we did not find any treatment‐related adverse or toxic effects on the examination of clinical signs, body weight, organ weight, serum biochemistry, hematology, gross, and microscopic anatomic pathological examination. These results demonstrated that the Lp590 is as safe as Lp in our subchronic feeding trial. Practical applicationsThe purpose of this study is to evaluate the safety of transformed Lactobacillus plantarum. In this current 90‐day feeding study, body weight, feed consumption and toxicological response variables (hematological parameters, serum chemistry, absolute, and relative organ weight) were measured, and gross as well as microscopic pathology were examined. No adverse effects were observed on animals. The results indicated that Lp590 is as safe as Lp. The result can add the safety evidence of transformed microorganism.
Source: Journal of Food Safety - Category: Food Science Authors: Tags: ORIGINAL ARTICLE Source Type: research