Extracellular matrix (ECM) activates {beta}-catenin signaling in uterine fibroids

In conclusion, our data showed that β-catenin expression in fibroids occurs independently of MED12 mutations. Biomechanical changes upregulate β-catenin expression in fibroids, providing an attractive avenue for developing new treatments for this disease.

Source: Reproduction - December 21, 2017 Category: Reproduction Medicine Authors: Ko, Y.-A., Jamaluddin, M. F. B., Adebayo, M., Bajwa, P., Scott, R. J., Dharmarajan, A. M., Nahar, P., Tanwar, P. S. Tags: Research Source Type: research