[Correspondence] Interferonopathies in laboratory-negative suspected congenital infection

We read Delan Devakumar and colleagues' Review1 of infectious causes of microcephaly with interest. This Review describes the major congenital infections that cause microcephaly and substantial neurological impairment worldwide, focusing on pathogenesis, diagnosis, and management. As the Review discusses congenital infection (with reference to pitfalls in diagnosis), it is also worth noting the interferonopathies, also called Aicardi-Gouti ères syndrome. The interferonopathies are a spectrum of disorders that should be considered in infants with suspected congenital infection and negative results in laboratory tests, including for cytomegalovirus, rubella, herpes simplex virus, toxoplasmosis, and Zika virus.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research