The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies
Primary testicular lymphomas (PTL) are the most prevalent type of testicular cancer arising in men over the age of 60. PTL accounts for approximately 1 –2% of all non-Hodgkin lymphomas and most present with localized disease but despite this, outcome is poor. The majority of cases represent an extranodal manifestation of diffuse large B-cell lymphoma (DLBCL), known as primary testicular DLBCL (PT-DLBCL). Gene expression profiling has established that over 75% of PT-DLBCLs resemble the activated B-cell-like (ABC) or non-germinal center subtype of nodal DLBCL.
Source: Blood Reviews - Category: Hematology Authors: David D.W. Twa, Anja Mottok, Kerry J. Savage, Christian Steidl Tags: Review Source Type: research
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