Efficacy and Safety Comparison Between Suberoylanilide Hydroxamic Acid and Mitomycin C in Reducing the Risk of Corneal Haze After PRK Treatment In Vivo

Corneal haze formation involves changes in extracellular matrix deposition and keratocyte proliferation, migration, apoptosis, and differentiation of fibroblasts and myofibroblasts.1 –4 Transforming growth factor beta-1 (TGF-β1) has been shown to play a central role in myofibroblast generation and corneal haze formation.5 Myofibroblasts are opaque cells with high contractibility, show de novo expression of alpha-smooth muscle actin (α-SMA), and synthesize extracellular matri x protein. Accumulating literature reveals that myofibroblasts are responsible for corneal haze/fibrosis, but the exact

Source: Journal of Refractive Surgery - December 12, 2017 Category: Opthalmology Authors: Govindaraj Anumanthan, PhD Source Type: research