Editorial comment: Mitochondrial autophagy in cardiac aging is all fluxed up

Functional decline towards cellular senescence presents a different set of problems in cardiomyocytes relative to proliferative cells. For example, senescence of proliferative cells serves an important tumor-suppressive role by promoting cell-cycle exit [1]. However, in non-proliferative and long-lived cardiomyocytes, senescence as a consequence of years of cumulative stress from aging may play a detrimental role and contribute to functional decline due to accumulation of damaged proteins, dysfunctional organelles, and DNA damage.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research