Reduced insulin sensitivity may be related to less striatal glutamate: An 1H-MRS study in healthy non-obese humans

Levels of striatal dopamine (DA) may be positively correlated with levels of striatal glutamate (Glu). While reduced insulin sensitivity (%S) has been associated with reduced striatal DA levels in healthy non-obese persons, whether reduced %S is also associated with reduced striatal Glu levels has not yet been established. Using 1H-MRS, we measured levels of several neurometabolites in the striatum and dorsolateral prefrontal cortex (DLPFC) of seventeen healthy non-obese persons (9 female, mean age: 28.35 ± 9.53).

Source: European Neuropsychopharmacology - December 18, 2017 Category: Psychiatry & Psychology Authors: Fernando Caravaggio, Yusuke Iwata, Eric Plitman, Sofia Chavez, Carol Borlido, Jun Ku Chung, Julia Kim, Sri Mahavir Agarwal, Philip Gerretsen, Gary Remington, Margaret Hahn, Ariel Graff-Guerrero Source Type: research