Endocardial Activation Drives Activation Patterns During Long-Duration Ventricular Fibrillation and Defibrillation [Original Articles]

Conclusions
The results showed that the chaotic pattern was predominant in early VF, but the regular pattern emerges as VF progressed. The synchronized pattern only emerged occasionally during late VF. Failed defibrillation shocks changed chaotic and regular activation patterns to synchronized patterns in LDVF but not in short-duration VF. The regular and synchronized patterns of activation were driven by rapid activations on the endocardial surface that blocked and broke up transmurally, leading to an endocardial to epicardial activation rate gradient as LDVF progressed.

Source: Circulation: Arrhythmia and Electrophysiology - December 15, 2017 Category: Cardiology Authors: Panitchob, N., Li, L., Huang, J., Ranjan, R., Ideker, R. E., Dosdall, D. J. Tags: Arrhythmias, Electrophysiology, Ventricular Fibrillation, Animal Models of Human Disease Original Articles Source Type: research