Physiological and pathological relevance of cell competition in fly to mammals

In multicellular organisms, incidentally emerging suboptimal cells are removed to maintain homeostasis of tissues. The unfavorable cells are excluded by a process termed cell competition whereby the resident normal cells actively eliminate the unfit cells of the identical lineage. Although the phenomenon of cell competition was originally discovered in Drosophila, a number of recent studies have provided implications of cell competition in tissue regeneration, development and oncogenesis in mammals. Here the roles of cell competition in fly to mammals are discussed. The incidentally emerging suboptimal cells are eradicated by a process termed cell competition whereby the resident normal cells actively eliminate the unfit cells. In this review article, diverse roles of cell competition in development, tissue repair and oncogenesis are discussed.
Source: Development, Growth and Differentiation - Category: Research Authors: Tags: Review Article Source Type: research