Codon optimality, bias and usage in translation and mRNA decay

Nature Reviews Molecular Cell Biology 19, 20 (2018). doi:10.1038/nrm.2017.91 Authors: Gavin Hanson & Jeff Coller The advent of ribosome profiling and other tools to probe mRNA translation has revealed that codon bias — the uneven use of synonymous codons in the transcriptome — serves as a secondary genetic code: a code that guides the efficiency of protein production, the fidelity
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research