Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor [Original Articles]

Conclusions:
Myh6-sTNF mice with sustained inflammatory signaling develop proteasome dysfunction and impaired autophagic flux that is associated with enhanced mTORC1 activation.

Source: Circulation: Heart Failure - December 4, 2017 Category: Cardiology Authors: Hartupee, J., Szalai, G. D., Wang, W., Ma, X., Diwan, A., Mann, D. L. Tags: Basic Science Research, Inflammation, Myocardial Biology, Heart Failure, Inflammatory Heart Disease Original Articles Source Type: research